Identification of a photoredox-active Pt(IV) complex that induces light-mediated cell death
We report the synthesis and characterisation of a series of fluorogenic Pt(IV) complexes - CarboBlue, OxaliBlue and CisBlue. These Pt(IV) complexes were identified as photoactive, oxidising biomolecules under light irradation to then undergo rapid intramolecular photoreduction to release the fluorescent reporter, Nap-OH and corresponding Pt(II) species. OxaliBlue and CisBlue displayed cytotoxicity regardless of light irradiation. In contrast, HCT116 cells treated with CarboBlue displayed a light-dependent increase in fluorescence emission along with selective light-induced toxicity.
Authors
- Rebecca A. Musgrave (ORCID: https://orcid.org/0000-0001-9404-0422)
- Ester M. Hammond (ORCID: https://orcid.org/0000-0002-2335-3146)
- Adam C. Sedgwick (ORCID: https://orcid.org/0000-0002-3132-2913)
- Ismael Díez‐Pérez (ORCID: https://orcid.org/0000-0003-0513-8888)
- Lina Hacker (ORCID: https://orcid.org/0000-0001-5160-0952)
- Sophie A. Twigger (ORCID: https://orcid.org/0000-0002-9066-7700)
- Carlos Romero (ORCID: https://orcid.org/0000-0002-5316-8312)
- Shitong Huang
- Jevon W. Marsh
- Jake A Vickery
- Anne L Langston
Institutions
- Mansfield University (US)
- King's College London (GB)
- Oxford Research Group (GB)
- Trinity College London (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Chemical Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5sc02879e
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00