Spleen granulopoiesis in psoriasis immune microenvironment aggravates psoriasis via IL-6/P-STAT3 signaling
The spleen plays a crucial role in the immune microenvironment of psoriasis as a major site of granulopoiesis, influencing neutrophil infiltration in the skin of psoriatic mice. Additionally, IL-6 is a key regulator of neutrophil formation in the spleen of psoriatic mice, likely through P-STAT3-dependent mechanisms.
Authors
- Pixia Gong (ORCID: https://orcid.org/0000-0002-7766-3270)
- Yayun Ding
- Weidong Zhu (ORCID: https://orcid.org/0000-0001-7180-6210)
- Chenxi Shi
- Feng Shi (ORCID: https://orcid.org/0009-0007-5175-7432)
- Chang Qi (ORCID: https://orcid.org/0000-0002-0736-7927)
- Zhe Lei (ORCID: https://orcid.org/0000-0002-5220-7391)
- Shan Huang
Institutions
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13062-025-00675-2
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Nanjing Medical University