Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells
This study elucidates the mechanisms by which lenvatinib-resistant HCC cells evade cuproptosis, highlighting the therapeutic potential of quercetin and ES-Cu combination treatment as a novel strategy to overcome lenvatinib resistance in HCC.
Authors
- Peixian Pi (ORCID: https://orcid.org/0000-0003-0404-4679)
- Hao Yang (ORCID: https://orcid.org/0000-0002-3781-7271)
- Qiwei Tian
- Tiantian Wu (ORCID: https://orcid.org/0000-0003-3846-6052)
- Beibei Liang (ORCID: https://orcid.org/0000-0002-5363-6315)
- Xiuhong Lu
- Haibo Wang (ORCID: https://orcid.org/0000-0003-4809-4897)
- Lu Yang (ORCID: https://orcid.org/0000-0002-5428-7874)
- Ming Ma
- Gang Huang (ORCID: https://orcid.org/0000-0002-5786-7110)
- Yutong Jiang (ORCID: https://orcid.org/0000-0003-0466-1300)
- Jian Zhao (ORCID: https://orcid.org/0000-0001-8131-8886)
- Mingzhu Zhang (ORCID: https://orcid.org/0009-0005-0751-210X)
- Zhiyu Zhang
- Lijuan Qing
Institutions
- Jiading District Central Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.066
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Key Laboratory of Molecular Imaging
- National Key Research and Development Program of China