Understanding the Interaction Between Premature Ageing in HIV and COPD Using Epigenetic Clocks: A Case–Control Study Protocol
We hypothesise that patients with both COPD and HIV will exceed the cumulative ageing effect of each condition separately, which suggests a multiplicative effect of ageing between HIV and COPD. Should our hypothesis be supported, it could justify a re-evaluation and potential modification of current screening protocols for COPD in HIV patients or the implementation of case-finding strategies.
Authors
- Melchor Riera (ORCID: https://orcid.org/0000-0002-0887-8710)
- Meritxell Gavaldà
- Francisco Fanjul (ORCID: https://orcid.org/0000-0003-1852-0330)
- José Luis Valera (ORCID: https://orcid.org/0000-0001-6360-4504)
- Rebecca Rowena Peña (ORCID: https://orcid.org/0009-0008-5500-2202)
- Ernest Sala (ORCID: https://orcid.org/0000-0002-6499-1638)
- Borja G. Cosío (ORCID: https://orcid.org/0000-0002-6388-8209)
- Marta González‐Freire (ORCID: https://orcid.org/0000-0001-9741-2826)
Institutions
- Universidad Francisco de Vitoria (ES)
Publication Details
- Journal
- Open Respiratory Archives
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.opresp.2025.100489
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00