Central Nervous System Outcomes of Lazertinib Treatment in EGFR-Mutated Advanced NSCLC: Pooled Analysis From LASER201 and LASER301
In this pooled analysis of LASER201 and LASER301, lazertinib demonstrated a clinically meaningful treatment benefit and consistent safety profile in patients with EGFR-mutated advanced NSCLC and CNS metastases.
Authors
- Joo-Hang Kim (ORCID: https://orcid.org/0000-0003-0408-8997)
- Sergey Orlov (ORCID: https://orcid.org/0000-0002-3134-1989)
- Ki Hyeong Lee (ORCID: https://orcid.org/0000-0002-7830-5950)
- Yun‐Gyoo Lee (ORCID: https://orcid.org/0000-0002-2156-5081)
- Yukyung Kim (ORCID: https://orcid.org/0000-0003-4922-9554)
- Ji‐Youn Han (ORCID: https://orcid.org/0000-0001-5033-0006)
- Yueh Ni Lim
- H.B. Cho
- Myung‐Ju Ahn (ORCID: https://orcid.org/0000-0002-5740-9654)
- Mi Jung Kwon (ORCID: https://orcid.org/0000-0002-2441-0448)
- James Chih‐Hsin Yang (ORCID: https://orcid.org/0000-0002-5586-5138)
- Byoung Chul Cho (ORCID: https://orcid.org/0000-0002-5562-270X)
- Chun Sen Lim
- Youngjoo Lee (ORCID: https://orcid.org/0000-0003-0180-189X)
- Hana Lee (ORCID: https://orcid.org/0000-0002-4059-4195)
- Kyung-Hee Lee (ORCID: https://orcid.org/0000-0002-2192-3328)
- Dong‐Wan Kim
- Young Joo Min
- Anastasia Zimina
- Sung Sook Lee
Institutions
- Ulsan College (KR)
- Yonsei University (KR)
- First Pavlov State Medical University of St. Petersburg (RU)
- Sarawak General Hospital (MY)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Sultan Ismail Specialist Hospital (MY)
- University of Ulsan (KR)
- National Cancer Center (US)
- Budgetary Health Care Institution of the Omsk Region "Clinical Oncology Center" (RU)
- Yuhan (South Korea) (KR)
- Inje University Haeundae Paik Hospital (KR)
- Kangbuk Samsung Hospital (KR)
- National Cancer Center (KR)
- National Taiwan University Hospital (TW)
- CHA University Bundang Medical Center (KR)
- Ulsan University Hospital (KR)
- CHA University (KR)
- Yeungnam University Medical Center (KR)
- Yonsei University Health System (KR)
- Chungbuk National University Hospital (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Clinical Lung Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.cllc.2025.08.007
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Yuhan