Landscape of genomic alterations and clinical outcomes in low-grade serous ovarian cancer in Korea
This study identifies frequent MAPK pathway mutations, including <i>KRAS</i> and <i>BRAF</i>, and a prevalence of <i>BRCA1/2</i> mutations in low-grade serous ovarian cancer. Compared to Western cohorts, <i>KRAS</i> and <i>BRAF</i> mutations were observed at relatively lower frequencies, highlighting potential regional differences in the molecular landscape of low-grade serous ovarian cancer.
Authors
- Yu-Seon Shim
- Myong Cheol Lim (ORCID: https://orcid.org/0000-0001-8964-7158)
- Sang‐Soo Seo (ORCID: https://orcid.org/0000-0003-2381-0965)
- Sangyoon Park (ORCID: https://orcid.org/0000-0001-8779-6694)
- Ji Hyun Kim (ORCID: https://orcid.org/0000-0002-8197-678X)
- Shan Kang (ORCID: https://orcid.org/0000-0001-7790-2393)
Institutions
- Seoul National University (KR)
- National Cancer Center (US)
- National Cancer Center (KR)
Publication Details
- Journal
- Gynecologic Oncology Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.gore.2025.101934
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00