Anti-Glioblastoma Effects of Dorzolamide Alone and in Combination with Temozolomide on U87 Cells and CD133+ Glioblastoma Stem Cells
Dorzolamide inhibits GSC proliferation, promotes apoptosis in U87 cells, affects the cell cycle, and enhances TMZ activity, suggesting potential in GBM treatment.
Authors
- Iffat Raza
- Lubna Khan (ORCID: https://orcid.org/0009-0001-3879-4702)
- Farina Hanif (ORCID: https://orcid.org/0000-0002-7458-8367)
- Sahar Mubeen (ORCID: https://orcid.org/0000-0002-8111-3431)
- Bushra Wasim (ORCID: https://orcid.org/0000-0001-8929-7389)
- Nadia Naeem (ORCID: https://orcid.org/0000-0003-1970-7340)
- Najia Karim Ghanchi
- SN SHAIKH
- Kanwal Naz
Institutions
- Aga Khan University (PK)
- Dow University of Health Sciences (PK)
- National University of Medical Sciences (PK)
- Ziauddin University (PK)
Publication Details
- Journal
- Current Molecular Medicine
- Published
- 2025-08-28
- DOI
- https://doi.org/10.2174/0115665240391781250731145446
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00