IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis
Our findings reveal a novel EC-TEC crosstalk axis mediated by reciprocal IGFBP-5/TGF-β1 signalling, which is a critical driver of renal fibrosis. IGFBP-5 emerges as a promising therapeutic target for inhibiting renal fibrogenesis in CKD.
Authors
- Guangyan Cai (ORCID: https://orcid.org/0009-0000-4446-1819)
- John Cijiang He (ORCID: https://orcid.org/0000-0002-1502-2849)
- Chengcheng Song (ORCID: https://orcid.org/0009-0002-1785-323X)
- Chao Liu (ORCID: https://orcid.org/0000-0003-3300-1360)
- Di Wu (ORCID: https://orcid.org/0000-0002-1929-3064)
- Xiaodong Geng (ORCID: https://orcid.org/0000-0003-1273-4979)
- Zhangning Fu
- Kun Chi (ORCID: https://orcid.org/0000-0002-9211-1992)
- Shuqiang Wang (ORCID: https://orcid.org/0000-0003-1119-320X)
- Xiangmei Chen (ORCID: https://orcid.org/0000-0001-8774-6021)
- Xueguang Zhang (ORCID: https://orcid.org/0000-0001-5458-8354)
- Quan Hong
Institutions
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- James J. Peters VA Medical Center (US)
- Peking University Shenzhen Hospital (CN)
- Chinese People's Liberation Army (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1093/ndt/gfaf179
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43