Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors: a win ratio analysis of the NOAH-AFNET 6 trial
This hypothesis-generating win ratio analysis, integrating death, thrombotic events, and major bleeds with and without quality of life, did not find an advantage of anticoagulation with edoxaban over no anticoagulation in patients with DDAF. The most common events were death and major bleeding.
Authors
- Éloi Marijon (ORCID: https://orcid.org/0000-0001-7227-3428)
- Wolfgang Dichtl (ORCID: https://orcid.org/0000-0002-0421-2110)
- Tobias Toennis (ORCID: https://orcid.org/0000-0002-7351-0621)
- Andrzej Lubiński (ORCID: https://orcid.org/0000-0003-2779-0041)
- Emanuele Bertaglia (ORCID: https://orcid.org/0000-0002-3878-2904)
- Gheorghe‐Andrei Dan (ORCID: https://orcid.org/0000-0001-9867-2582)
- Carina Blomström‐Lundqvist (ORCID: https://orcid.org/0000-0003-2806-3903)
- Lieven Nils Kennes (ORCID: https://orcid.org/0000-0002-2843-9192)
- Hans‐Christoph Diener (ORCID: https://orcid.org/0000-0002-6556-8612)
- Andreas Goette (ORCID: https://orcid.org/0000-0002-8223-7209)
- Εmmanuel Simantirakis (ORCID: https://orcid.org/0000-0001-9615-6293)
- Nuno Cabanelas
- Vasil Velchev (ORCID: https://orcid.org/0009-0008-2550-835X)
- Axel Brandes (ORCID: https://orcid.org/0000-0001-9145-6887)
- Kim Rajappan (ORCID: https://orcid.org/0000-0001-8996-2983)
- Ulrich Schotten (ORCID: https://orcid.org/0000-0003-1532-3315)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Nina Becher (ORCID: https://orcid.org/0000-0002-4476-1341)
- Lluı́s Mont (ORCID: https://orcid.org/0000-0002-8115-5906)
- Antonia Zapf (ORCID: https://orcid.org/0000-0002-8467-0508)
- Susanne Sehner (ORCID: https://orcid.org/0000-0002-2415-9302)
- Melanie Calvert (ORCID: https://orcid.org/0000-0002-1856-837X)
- Gregory Chlouverakis (ORCID: https://orcid.org/0000-0002-2855-772X)
- Andrea Sarkozy (ORCID: https://orcid.org/0000-0001-6327-0487)
- Dan Wichterle (ORCID: https://orcid.org/0000-0002-0448-5143)
- Joris R. de Groot (ORCID: https://orcid.org/0000-0002-8122-7017)
- Vincent Beuger (ORCID: https://orcid.org/0009-0008-8599-808X)
- Ursula Rohrer (ORCID: https://orcid.org/0000-0002-5278-6362)
- Alexander Fierenz (ORCID: https://orcid.org/0000-0002-5233-215X)
- Béla Merkely
- Panos Vardas
- Gregory Y. H. Lip
- A. John Camm
- Gina Köllner
Institutions
- Semmelweis University (HU)
- Uppsala University (SE)
- University of Padua (IT)
- University of Crete (GR)
- Innsbruck Medical University (AT)
- University of Liverpool (GB)
- Universität Hamburg (DE)
- Carol Davila University of Medicine and Pharmacy (RO)
- St George's, University of London (GB)
- University of Southern Denmark (DK)
- City, University of London (GB)
- Medical University of Graz (AT)
- Paderborn University (DE)
- Örebro University (SE)
- John Radcliffe Hospital (GB)
- Medical University of Sofia (BG)
- Academia Oamenilor de Știință din România (RO)
- Maastricht University (NL)
- Institut für Medizinische Informatik, Biometrie und Epidemiologie (DE)
- Liverpool Heart and Chest Hospital (GB)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Hospital Prof. Dr. Fernando Fonseca (PT)
- Hôpital Européen Georges-Pompidou (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Atrial Fibrillation NETwork (DE)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Universitair Ziekenhuis Brussel (BE)
- German Centre for Cardiovascular Research (DE)
- Institute of Clinical and Experimental Medicine (CZ)
- Brüderkrankenhaus St. Josef Paderborn (DE)
- St. Vincenz-Krankenhaus Limburg (DE)
- Hospital South West Jutland (DK)
- University Hospital of Heraklion (GR)
- European Hospital (IT)
- University of Applied Sciences Stralsund (DE)
- Amsterdam University Medical Centers (NL)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Duisburg-Essen (DE)
- Gdańsk Medical University (PL)
- University of Birmingham (GB)
- Aalborg University (DK)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- European Heart Journal - Quality of Care and Clinical Outcomes
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1093/ehjqcco/qcaf087
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Kompetenznetz Vorhofflimmern
- British Heart Foundation
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Frauen
- Daiichi Sankyo Europe