A comprehensive water buffalo pangenome reveals extensive structural variation linked to population-specific signatures of selection
This study represents one of the first successful applications of graph genomics in water buffalo and offers valuable insights into how integrating assemblies can transform analyses of water buffalo and other species with complex evolutionary histories. We anticipate that these assemblies, as well as the pangenome and putative functional structural variants we have released, will accelerate efforts to unlock water buffalo's genetic potential, improving productivity and resilience in this economically important species.
Authors
- Muhammad Mohsin (ORCID: https://orcid.org/0000-0001-7101-6323)
- Andrea Talenti (ORCID: https://orcid.org/0000-0003-1309-3667)
- S. Jayaraman (ORCID: https://orcid.org/0000-0003-1524-2232)
- Rachel S. Owen (ORCID: https://orcid.org/0000-0001-6441-2213)
- Shahid Mansoor (ORCID: https://orcid.org/0000-0001-7418-1826)
- James Prendergast (ORCID: https://orcid.org/0000-0001-8916-018X)
- Fazeela Arshad (ORCID: https://orcid.org/0000-0002-9149-2199)
- Muhammad Asif (ORCID: https://orcid.org/0000-0001-8508-903X)
Institutions
- National Institute for Biotechnology and Genetic Engineering (PK)
- Roslin Institute (GB)
- Pakistan Institute of Engineering and Applied Sciences (PK)
- University of Karachi (PK)
Publication Details
- Journal
- GigaScience
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gigascience/giaf099
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Commonwealth Scholarship Commission
- Biotechnology and Biological Sciences Research Council