Cisplatin-induced acute kidney injury is alleviated by BMSCs-derived exosome via mmu-miR-874-3p-mediated activation of the wnt/β-catenin signaling pathway
BMSCs-exo protect kidneys against cisplatin-induced AKI(<i>Cis</i>-AKI) by attenuating injury to the renal microvasculature and tubule epithelial cells, primarily through mmu-miR-874-3p-mediated inhibition of FZD5 activation and promotion of Wnt/β-catenin pathway activation.
Authors
- Deyang Kong
- Shuo Pang (ORCID: https://orcid.org/0000-0003-3753-1705)
- Umer Anayyat (ORCID: https://orcid.org/0009-0006-0930-1258)
- Yanping Li (ORCID: https://orcid.org/0000-0002-0412-2748)
- Xiaoting Zhang (ORCID: https://orcid.org/0009-0005-9846-8924)
- Yifan Song (ORCID: https://orcid.org/0000-0002-1621-9555)
- Z. W. Ou (ORCID: https://orcid.org/0000-0002-3632-474X)
- Hao Liu (ORCID: https://orcid.org/0000-0002-0879-0233)
- Zhangchang Yang (ORCID: https://orcid.org/0000-0002-2739-1916)
Institutions
- Harbin Medical University (CN)
- Shenzhen University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Hegang People's Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Dà-Jiāng Innovations Science and Technology (China) (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.reth.2025.08.016
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42