Pulmonary T2* quantification of fetuses with congenital diaphragmatic hernia: a retrospective, case-controlled, MRI pilot study
This study provides original motion-corrected assessment of the morphologic and functional properties of the ipsilateral and contralateral fetal lungs in the context of CDH. Mean pulmonary T2* values were lower in CDH fetuses compared to controls and in cases who died compared to survivors. Mean pulmonary T2* values may have a role in prognostication. Reduction in pulmonary T2* values in CDH fetuses suggests altered pulmonary development, contributing new insights into antenatal assessment.
Authors
- Alexia Egloff (ORCID: https://orcid.org/0000-0002-2005-8328)
- Maria Deprez (ORCID: https://orcid.org/0000-0002-2799-6077)
- Alena Uus (ORCID: https://orcid.org/0000-0001-5796-2145)
- Jana Hutter (ORCID: https://orcid.org/0000-0003-3476-3500)
- Carla L. Avena-Zampieri (ORCID: https://orcid.org/0000-0002-5455-2789)
- Kelly Payette (ORCID: https://orcid.org/0000-0001-7041-0150)
- Joseph Davidson (ORCID: https://orcid.org/0000-0002-3303-6320)
- Mary Rutherford (ORCID: https://orcid.org/0000-0003-3361-1337)
- Anne Greenough (ORCID: https://orcid.org/0000-0002-8672-5349)
- Lisa Story (ORCID: https://orcid.org/0000-0001-9328-9592)
- Caroline L. Knight (ORCID: https://orcid.org/0000-0002-0970-9687)
- Megan P. Hall
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Great Ormond Street Hospital (GB)
- Universitätsklinikum Erlangen (DE)
- Evelina London Children's Healthcare (GB)
- University College London (GB)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1038/s41390-025-04091-0
- Citations
- 1
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01