Heterogeneous cardiovascular effects of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes: a causal forest and target trial emulation study
The cardioprotective effect of SGLT2i was heterogeneous and more strongly predicted by individual patient characteristics than by overall CVD risk score, highlighting the importance of considering its benefit beyond the conventional risk stratification approach.
Authors
- Yusuke Tsugawa (ORCID: https://orcid.org/0000-0002-1937-4833)
- Motoko Yanagita (ORCID: https://orcid.org/0000-0002-0339-9008)
- Ryuichiro Yagi (ORCID: https://orcid.org/0000-0003-1502-039X)
- Shingo Fukuma (ORCID: https://orcid.org/0000-0002-8379-8761)
- Daisuke Yabe (ORCID: https://orcid.org/0000-0002-5334-7687)
- Naoki Kondo (ORCID: https://orcid.org/0000-0002-6425-6844)
- Motohiko Adomi (ORCID: https://orcid.org/0000-0003-4277-4509)
- Kosuke Inoue (ORCID: https://orcid.org/0000-0001-9614-8103)
- Toshiaki Komura (ORCID: https://orcid.org/0009-0001-1514-3288)
- Yuichiro Mori (ORCID: https://orcid.org/0000-0001-7211-8970)
- Koji Kawakami
Institutions
- Boston University (US)
- Hiroshima University (JP)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Kyoto University (JP)
- UCLA Health (US)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/eurjpc/zwaf539
- Citations
- 2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.59