When age meets genetics: refining heart failure risk prediction in young atrial fibrillation

We read with interest Ahn et al.'s analysis from the UK Biobank evaluating whether a heartfailure (HF) polygenic risk score (PRS) improves risk prediction in younger patients with atrial fibrillation (AF) [1].The authors report modest incremental discrimination and a stronger relative association of higher PRS with HF in those <60 years, an observation consistent with the notion that genetic risk exerts greater influence earlier in life. Key considerations.