Aortic valve replacement and mortality in asymptomatic individuals with severe aortic stenosis and left ventricular hypertrophy
AVR was associated with reduced mortality for patients with severe asymptomatic AS, preserved LVEF, and LVH. This is the largest known analysis of aortic valve replacement outcomes in individuals with severe aortic stenosis and left ventricular hypertrophy. As clinical guidelines for intervention in asymptomatic severe aortic stenosis expand, left ventricular hypertrophy is easier to assess than myocardial fibrosis and may be a useful marker for patients who need to be prioritized. These results raise the potential of more proactive AVR in individuals with LVH, even among asymptomatic individuals with normal LVEF.
Authors
- Meagan M. Wasfy (ORCID: https://orcid.org/0000-0003-0398-0481)
- Muhammad Etiwy (ORCID: https://orcid.org/0000-0002-4325-1921)
- Michael H. Picard (ORCID: https://orcid.org/0000-0002-9264-3243)
- Adam N. Berman (ORCID: https://orcid.org/0000-0002-0724-9779)
- Nicole Karam (ORCID: https://orcid.org/0000-0002-3861-6914)
- Sarah Gustus
- Chiara Fraccaro (ORCID: https://orcid.org/0000-0002-3972-4642)
- Jason H. Wasfy (ORCID: https://orcid.org/0000-0002-0871-5970)
- Yunong Zhao (ORCID: https://orcid.org/0000-0003-2439-8669)
- John Hsu
Institutions
- Dartmouth College (US)
- Harvard University (US)
- University of Padua (IT)
- Massachusetts General Hospital (US)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- New York University (US)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1093/ejcts/ezaf211
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00