Comparative effectiveness of alternative initial doses of opioid agonist treatment for individuals with opioid use disorder: a protocol for a retrospective population-based study using target trial emulation in British Columbia, Canada
The protocol, cohort creation and analysis plan have been classified and approved as a quality improvement initiative by Providence Health Care Research Ethics Board and the Simon Fraser University Office of Research Ethics. Results will be disseminated to local advocacy groups and decision-makers, national and international clinical guideline developers, presented at international conferences and published in peer-reviewed journals electronically and in print.
Authors
- Micah Piske
- Paxton Bach (ORCID: https://orcid.org/0000-0002-2413-9133)
- Ehsan Karim
- Uwe Siebert (ORCID: https://orcid.org/0000-0001-6425-7671)
- Jeong Eun Min
- Hui Xie (ORCID: https://orcid.org/0000-0003-3328-7135)
- M. Eugenia Socías (ORCID: https://orcid.org/0000-0003-2556-7049)
- Kirsty Smith (ORCID: https://orcid.org/0000-0003-0898-4991)
- Shaun R. Seaman (ORCID: https://orcid.org/0000-0003-3726-5937)
- Bohdan Nosyk (ORCID: https://orcid.org/0000-0003-2513-3718)
- Robert W. Platt (ORCID: https://orcid.org/0000-0002-5981-8443)
- Megan Kurz
- Ruyu Yan
- Md. Belal Hossain (ORCID: https://orcid.org/0000-0003-4603-863X)
Institutions
- University of British Columbia Hospital (CA)
- Harvard University (US)
- University of British Columbia (CA)
- Simon Fraser University (CA)
- Massachusetts General Hospital (US)
- British Columbia Centre on Substance Use (CA)
- UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik (AT)
- MRC Biostatistics Unit (GB)
- Centre for Advancing Health Outcomes (CA)
- McGill University (CA)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/bmjopen-2025-098990
- Citations
- 1
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Institutes of Health
- National Institute on Drug Abuse