Regulatory polymorphisms of <i>MSH6</i>, <i>MSH2</i>, <i>FBXO11,</i> and <i>PPP1R21</i> genes affect survival of patients with immunotherapy-treated lung cancer
This study identifies an association between a genomic locus on chromosome 2 and OS in patients with NSCLC treated with ICI. Although these results need validation in larger cohorts and functional studies to elucidate the underlying mechanisms, they highlight the potential of germline variants as predictive biomarkers of response to ICI.
Authors
- Elena Collovà
- Claudia Bareggi
- Luca Toschi (ORCID: https://orcid.org/0000-0002-4023-7542)
- Luca Sala (ORCID: https://orcid.org/0000-0003-4568-5739)
- Arianna Pagliaro (ORCID: https://orcid.org/0009-0000-3752-8253)
- Eleonora Mangano (ORCID: https://orcid.org/0000-0002-4040-4654)
- Francesca Colombo (ORCID: https://orcid.org/0000-0003-2015-4317)
- Francesca Minnai (ORCID: https://orcid.org/0000-0003-3646-3800)
- Manuela Gariboldi (ORCID: https://orcid.org/0000-0001-8406-165X)
- Gabriella Farina
- Diego Cortinovis (ORCID: https://orcid.org/0000-0001-7611-7369)
- Elisa Frullanti (ORCID: https://orcid.org/0000-0001-5634-031X)
- Tania Camboni
- Sara Noci (ORCID: https://orcid.org/0000-0002-6227-3907)
- Sheila Piva (ORCID: https://orcid.org/0000-0003-1808-2430)
- Serena Girelli
- Martina Esposito (ORCID: https://orcid.org/0009-0007-4118-3893)
Institutions
- University of Siena (IT)
- University of Milan (IT)
- National Academies of Sciences, Engineering, and Medicine (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute of Biomedical Technologies (IT)
- National Research Council (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- ASST Fatebenefratelli Sacco (IT)
- Azienda Ospedaliera Ospedale Civile di Legnano (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/jitc-2025-011526
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- European Commission
- Ministero della Salute