Low-Intensity pulsed ultrasound enhances paracrine secretion of IGF and VEGF by bmscs, promoting osteogenesis and angiogenesis
LIPUS promotes osteogenic differentiation of BMSCs and angiogenesis in RAOECs through the paracrine signaling of BMSCs, at least by increasing IGF-1 and VEGF secretion. This suggests that LIPUS can regulate the secretome of BMSCs and may serve as a key mechanism in promoting bone tissue regeneration.
Authors
- Chuping Hou (ORCID: https://orcid.org/0000-0002-2729-6521)
- Ruijie Fu
- Chenfeng Chen
- Yihan Liao (ORCID: https://orcid.org/0000-0002-2622-9036)
- Wenchuan Chen (ORCID: https://orcid.org/0000-0002-6145-7878)
- Shuaiqi Gan (ORCID: https://orcid.org/0009-0005-3338-0921)
- Zheng Zheng (ORCID: https://orcid.org/0000-0003-3667-8959)
- Shuhan Yang (ORCID: https://orcid.org/0009-0001-8502-7098)
- Jia Xu
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Stomatology Hospital (CN)
- State Key Laboratory of Oral Diseases
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s12891-025-09027-7
- Citations
- 3
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- National Natural Science Foundation of China
- Sichuan University
- Natural Science Foundation of Sichuan Province