Intrahepatic Cholangiocarcinoma in Wilson’s Disease: 2 Case Reports

The occurrence of hepatobiliary malignancies in Wilson's disease is rare, even in cirrhotic patients. The exact reasons for this low prevalence are unclear, with some conflicting data. Copper's role in chromatin stabilization and angiogenesis, along with copper deficiency due to Wilson's disease and its treatment, may reduce tumour growth. The current guidelines do not have specific directives regarding cholangiocarcinoma screening in patients with cirrhosis secondary to Wilson's disease. Despite the lower incidence of malignancies in Wilson's disease, vigilant monitoring is advised.