Sex-dependent relationships between PFAS and placental transcriptomics identified by weighted gene co-expression analysis
One module showed a negative association with perfluorononanoic acid (PFNA; β = -0.012, q = 0.009). This association was sex-specific, with the sexes exhibiting varied PFAS associations but similar directional effects. Genes within the PFNA-associated module were involved in histone modification (q ≤ 0.05) and were enriched for targets of the Vitamin D Receptor (VDR), a transcription factor previously linked to PFAS.
Authors
- Aline Andres (ORCID: https://orcid.org/0000-0003-2611-2193)
- Kartik Shankar (ORCID: https://orcid.org/0000-0002-7964-9026)
- Dana Boyd Barr (ORCID: https://orcid.org/0000-0002-5566-2138)
- K. J. Pearson (ORCID: https://orcid.org/0000-0001-5848-7614)
- Kyle A. Campbell (ORCID: https://orcid.org/0000-0002-1836-0341)
- Clark Sims (ORCID: https://orcid.org/0000-0003-2730-7283)
- Todd M. Everson (ORCID: https://orcid.org/0000-0003-2732-4550)
- Cynthia Perez
Institutions
- Arkansas Children's Hospital (US)
- University of Kentucky (US)
- Emory University (US)
- Southern Plains Agricultural Research Center (US)
- Arkansas Children's Nutrition Center (US)
Publication Details
- Journal
- Environmental Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.envres.2025.122745
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00