Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis
The ontogenetic stage of donor cells plays a crucial role in EV's therapeutic efficacy, with fetal-derived EVs demonstrating superior outcomes compared to perinatal-derived EVs. The distinct effects of fCC-EVs and fMSC-EVs suggest that a combinatorial approach using both EV types could optimize therapeutic outcomes.
Authors
- Mario Rothbauer (ORCID: https://orcid.org/0000-0002-9928-3631)
- Matthias Hackl (ORCID: https://orcid.org/0000-0002-4136-7293)
- Angkana Kidtiwong (ORCID: https://orcid.org/0000-0003-2372-7256)
- Silvio Kau (ORCID: https://orcid.org/0000-0001-9538-9976)
- Christopher Gerner (ORCID: https://orcid.org/0000-0003-4964-0642)
- Regina Grillari‐Voglauer (ORCID: https://orcid.org/0000-0002-5487-2838)
- Giovanni Corso (ORCID: https://orcid.org/0000-0002-9269-0146)
- Stefan Toegel (ORCID: https://orcid.org/0000-0003-4317-1769)
- Florien Jenner (ORCID: https://orcid.org/0000-0002-6977-1984)
- Harini Nivarthi
- Andrea Bileck (ORCID: https://orcid.org/0000-0002-7053-8856)
- Salih Sinan Gültekin (ORCID: https://orcid.org/0000-0003-2458-3530)
- Johanna Gamauf
- Iris Gerner
- K. V. Tarasova
- Maria Belen Arteaga
Institutions
- University of Vienna (AT)
- University of Veterinary Medicine Vienna (AT)
- Evercyte (Austria) (AT)
- Austrian Cluster for Tissue Regeneration (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13287-025-04585-y
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Veterinärmedizinische Universität Wien