The role of ASS1 in mouse embryonic stem cell differentiation into mesendoderm lineages
ASS1 knockout directs mESCs toward mesendoderm lineage commitment, thereby promoting beating cardiomyocyte generation. Thus, ASS1 acts as a regulatory switch whose absence drives mesendoderm differentiation and enhances cardiomyocyte production.
Authors
- Qiaoqiao Meng
- Shuo Cao (ORCID: https://orcid.org/0009-0008-1838-2517)
- Xihe Li (ORCID: https://orcid.org/0000-0002-7001-7997)
- Siqin Bao (ORCID: https://orcid.org/0000-0002-9582-3194)
- Qian Jiang (ORCID: https://orcid.org/0000-0001-9872-758X)
- Yanglin Chen (ORCID: https://orcid.org/0000-0002-3980-7480)
- Baojiang Wu (ORCID: https://orcid.org/0000-0002-8224-6885)
- Guodong Zhao (ORCID: https://orcid.org/0000-0002-9016-6121)
Institutions
- Inner Mongolia Agricultural University (CN)
- Inner Mongolia University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13287-025-04622-w
- Citations
- 1
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81