Engineering modification of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorates polycystic ovary syndrome by enhancing the ovarian environment and regulating follicular development
In this study, we engineered sEVs to deliver the 740Y-P peptide, demonstrating their capacity to mitigate ovarian inflammation, normalize follicular development, and enhance fertility in a PCOS mouse model. These findings propose a novel therapeutic strategy for PCOS, pending further optimization of delivery protocols and clinical validation.
Authors
- Chun-Ru Song
- Chengguang Liang
- Fang-Rui Xue
- Jing Li (ORCID: https://orcid.org/0000-0001-8692-4981)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-9167-2077)
- Wei Liu (ORCID: https://orcid.org/0000-0002-9302-8170)
- Jun Zhai (ORCID: https://orcid.org/0000-0001-9566-865X)
- Ding Kang
- Yating Chen (ORCID: https://orcid.org/0000-0001-9165-8155)
- Yishan Dong (ORCID: https://orcid.org/0000-0002-2993-6588)
Institutions
- Inner Mongolia University (CN)
- Soochow University (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13287-025-04610-0
- Citations
- 3
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China