Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers
We demonstrated that biological aging was clearly increased in sex chromosome aneuploidies, especially TS, potentially contributing to the severely reduced lifespan. Additionally, unfavorable changes in body composition, common in both TS and KS, and in particular in the presence of hypogonadism, could result in accelerated aging-or be the result thereof.
Authors
- Anne Skakkebæk (ORCID: https://orcid.org/0000-0001-9178-4901)
- Claus Højbjerg Gravholt (ORCID: https://orcid.org/0000-0001-5924-1720)
- Emma B. Johannsen (ORCID: https://orcid.org/0000-0002-1017-7702)
- Simon Chang (ORCID: https://orcid.org/0000-0003-1130-3659)
- Jesper Just (ORCID: https://orcid.org/0000-0002-3825-0000)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13148-025-01963-4
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aarhus Universitet
- Danish Diabetes Academy
- Novo Nordisk
- Familien Hede Nielsens Fond
- Novo Nordisk Fonden
- Danmarks Frie Forskningsfond