Compatibility of Serratia ureylitica Su_YN1, Malaria Transmission-Blocking Bacterium, with the Anopheles aquasalis Vector
Malaria continues to affect millions of people around the world. Current control strategies have not been sufficient, and additional tools are required for malaria elimination. A promising approach is the use of bacteria from the mosquito microbiota, such as the Su_YN1 <i>Serratia ureilytica</i> bacterium, which is shown to strongly impair the development of <i>P. falciparum</i> and <i>P. berghei</i> in <i>Anopheles</i> mosquitoes. To evaluate the potential of using <i>S. ureilytica</i> Su_YN1 to block the <i>Plasmodium</i> parasite in South American vectors, we investigated its effects on mosquito fitness and survival. We found that this bacterium does not affect the longevity, blood feeding, fecundity and fertility of <i>Anopheles aquasalis</i>, an important South American vector. Overall, our results provide baseline support for the potential implementation of Su_YN1 for the control of malaria transmission in South America.
Authors
- Marcelo Jacobs‐Lorena (ORCID: https://orcid.org/0000-0003-0449-432X)
- Marília Ferreira Correia (ORCID: https://orcid.org/0000-0003-3748-1621)
- Sibao Wang (ORCID: https://orcid.org/0000-0002-5880-0815)
- Cláudia Maria Ríos-Velásquez (ORCID: https://orcid.org/0000-0002-2684-2981)
- Keillen Monick Martins-Campos (ORCID: https://orcid.org/0000-0002-5923-5002)
- Edson Júnior do Carmo (ORCID: https://orcid.org/0000-0002-2222-430X)
- Pritesh Lalwani (ORCID: https://orcid.org/0000-0003-2996-0446)
- Elerson Matos Rocha (ORCID: https://orcid.org/0000-0003-2322-3576)
- Elen Sabrina dos Reis Martins (ORCID: https://orcid.org/0000-0001-5890-4422)
- Rosemary Aparecida Roque (ORCID: https://orcid.org/0000-0002-8781-6170)
- Ricardo de Melo Katak (ORCID: https://orcid.org/0000-0001-5318-4884)
- Luciano Andrade Moreira (ORCID: https://orcid.org/0000-0002-9240-3506)
- Paulo Andrade
- L. O. Silva (ORCID: https://orcid.org/0000-0003-1218-8365)
Institutions
- Target (United States) (US)
- Johns Hopkins University (US)
- Instituto Nacional de Pesquisas da Amazônia (BR)
- Universidade Federal de Campina Grande (BR)
- Instituto de Ensino e Pesquisa Santa Casa (BR)
- Center for Excellence in Molecular Plant Sciences (CN)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- Tropical Medicine and Infectious Disease
- Published
- 2025-08-31
- DOI
- https://doi.org/10.3390/tropicalmed10090249
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado do Amazonas