Early-onset colorectal cancer patients exhibit a distinct molecular fingerprint: insights from a large-scale NGS study of 1209 patients
Patients with EO-CRC show a distinctive and biologically aggressive molecular profile, marked by significant changes in genes associated with cell proliferation and responses to environmental stress. These observations support the classification of EO-CRC as a potentially distinct clinical entity and suggest that personalised treatment strategies tailored to age-related molecular profiles warrant further investigation.
Authors
- Andrea Pretta (ORCID: https://orcid.org/0000-0002-0262-9270)
- M. Scartozzi
- Valeria Pusceddu (ORCID: https://orcid.org/0000-0003-4167-9091)
- C. Donisi
- Federica Marmorino (ORCID: https://orcid.org/0000-0001-7725-3434)
- C. Damonte (ORCID: https://orcid.org/0000-0003-0565-0478)
- A. De Rosa
- G. Pretta
- Isacco Montroni (ORCID: https://orcid.org/0000-0002-3769-8428)
- F. Bergamo
- Krisida Cerma
- Pina Ziranu (ORCID: https://orcid.org/0000-0002-5659-7366)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- G. Randon
- Vincenzo Nasca (ORCID: https://orcid.org/0000-0002-7897-402X)
- Martina Carullo (ORCID: https://orcid.org/0000-0003-2846-2517)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Paolo Ciracì (ORCID: https://orcid.org/0000-0002-3791-6288)
- F. Pietrantonio
- R. Intini
- Chiara Gaiani
- Ada Taravella (ORCID: https://orcid.org/0009-0000-2153-3867)
Institutions
- University of Pisa (IT)
- University of Cagliari (IT)
- Istituto Oncologico Veneto (IT)
- King's College School (GB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105756
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Cagliari
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca