Survivin Is a Central Mediator of Cell Proliferation in HPV-Negative Head and Neck Squamous Cell Carcinoma
Our findings highlight survivin as a critical mediator of cell proliferation in HPV<sup>-</sup> HNSCC and suggest that targeting the CDK4/6-USP1-survivin axis may offer a promising therapeutic strategy.
Authors
- Nicole Kawachi
- Nitisha Shrivastava (ORCID: https://orcid.org/0000-0003-4677-4178)
- Vikas Mehta (ORCID: https://orcid.org/0000-0002-0907-2102)
- Erqiang Hu (ORCID: https://orcid.org/0000-0002-1798-7513)
- Jing Zhu (ORCID: https://orcid.org/0000-0001-9081-6641)
- Gregory Rosenblatt
- Audrey Le Roy
- J. An (ORCID: https://orcid.org/0000-0001-6004-3713)
- Gabriela Berner (ORCID: https://orcid.org/0000-0002-1428-0491)
- Michael B. Prystowsky (ORCID: https://orcid.org/0000-0002-9548-6917)
- Jeffrey E. Segall (ORCID: https://orcid.org/0000-0001-5425-9315)
- Thomas J. Ow (ORCID: https://orcid.org/0000-0001-9389-2332)
Institutions
- Albert Einstein College of Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Montefiore Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-31
- DOI
- https://doi.org/10.3390/cancers17172864
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Price Family Foundation