AI-HOPE-TP53: A Conversational Artificial Intelligence Agent for Pathway-Centric Analysis of TP53-Driven Molecular Alterations in Early-Onset Colorectal Cancer
AI-HOPE-TP53, developed in this study and made publicly available, is the first conversational AI platform tailored for pathway-specific and disparity-aware EOCRC research. By integrating clinical, genomic, and demographic data through natural language interaction, hypothesis generation and equity-focused analyses are enabled, with significant potential to advance precision oncology.
Authors
- Enrique Velazquez‐Villarreal (ORCID: https://orcid.org/0000-0002-3603-6414)
- Ei-Wen Yang
- Brigette Waldrup (ORCID: https://orcid.org/0009-0009-5991-9779)
Institutions
- City of Hope (US)
- Beckman Research Institute
Publication Details
- Journal
- Cancers
- Published
- 2025-08-31
- DOI
- https://doi.org/10.3390/cancers17172865
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Institutes of Health