CK2α Overexpression in Colorectal Cancer: Evidence for Sex- and Age-Linked Differences
CK2α is significantly overexpressed in the tumor tissue of female CRC patients and shows a strong age-related correlation. These findings suggest a sex- and age-specific regulatory mechanism potentially influenced by estrogen signaling or menopause. Such dimorphisms underscore the need for sex-specific strategies in CRC biomarker development and therapy.
Authors
- J Friedrich
- Angela Brieger (ORCID: https://orcid.org/0000-0003-1089-9710)
- Guido Plotz (ORCID: https://orcid.org/0000-0001-5314-9739)
- Sarah J. Overby (ORCID: https://orcid.org/0000-0001-8195-9456)
- Stefan Zeuzem
- Clara Meier
Institutions
- Goethe University Frankfurt (DE)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3390/cancers17172857
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00