Mortalin Represents a Promising Therapeutic Target for Oral Cancers: Clinical Relevance and Experimental Evidence for the Activation of Akt/mTOR Signaling
Collectively, these data support mortalin as a potential therapeutic target for oral cancer and warrant further studies for the development of mortalin-targeting drugs in both laboratory and clinical settings.
Authors
- Gazi Naseem Ahmed
- Mangala Hegde (ORCID: https://orcid.org/0000-0003-2926-896X)
- Choudhary Harsha (ORCID: https://orcid.org/0000-0001-7854-2406)
- Ajaikumar B. Kunnumakkara (ORCID: https://orcid.org/0000-0001-9121-6816)
- Munindra Narayan Baruah (ORCID: https://orcid.org/0009-0008-1729-1381)
- Nafiseh Manteghi
- Imliwati Longkumer (ORCID: https://orcid.org/0000-0003-4009-9976)
- Renu Wadhwa (ORCID: https://orcid.org/0000-0001-8248-5192)
- Sosmitha Girisa (ORCID: https://orcid.org/0000-0003-0261-5538)
- Sunil C. Kaul
Institutions
- Indian Institute of Technology Guwahati (IN)
- Bhubaneswar Borooah Cancer Institute (IN)
- Cancer Hospital and Research Institute (IN)
- National Institute of Advanced Industrial Science and Technology (JP)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3390/cancers17172860
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Advanced Industrial Science and Technology
- Department of Biotechnology, Ministry of Science and Technology, India
- Ministry of Education, India
- Indian Institute of Technology Guwahati