Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever

This study reports a case of a 47-year-old female who was initially misdiagnosed as having liver abscess due to repeated fever, and was later misdiagnosed again as liver inflammatory myofibroblastic tumor(IMT) after liver biopsy. After surgical removal, molecular pathological examination confirmed the diagnosis of Hepatic epithelioid hemangioendothelioma(HEHE). HEHE with fever as the main symptom is extremely rare and there are no similar reports available at present. This study summarizes the key points of HEHE diagnosis and treatment, analyzes the reasons for the misdiagnosis in this case and the possible factors causing the fever symptoms, highlights the difficulties in HEHE diagnosis and the significant value of molecular pathology in its diagnosis.

Authors

Institutions

Publication Details

Journal
Frontiers in Oncology
Published
2025-09-01
DOI
https://doi.org/10.3389/fonc.2025.1606872
Primary Topic
Vascular Tumors and Angiosarcomas
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever

Jian Zhao, Yixuan Dang
Frontiers in Oncology
Vascular Tumors and Angiosarcomas
article

Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever

Jian Zhao, Yixuan Dang
article en

Abstract

This study reports a case of a 47-year-old female who was initially misdiagnosed as having liver abscess due to repeated fever, and was later misdiagnosed again as liver inflammatory myofibroblastic tumor(IMT) after liver biopsy. After surgical removal, molecular pathological examination confirmed the diagnosis of Hepatic epithelioid hemangioendothelioma(HEHE). HEHE with fever as the main symptom is extremely rare and there are no similar reports available at present. This study summarizes the key points of HEHE diagnosis and treatment, analyzes the reasons for the misdiagnosis in this case and the possible factors causing the fever symptoms, highlights the difficulties in HEHE diagnosis and the significant value of molecular pathology in its diagnosis.

Frontiers in OncologyVol. 15
Yunnan University (CN), Kunming Medical University (CN), First People's Hospital of Yunnan Province (CN)
National Natural Science Foundation of China, Yunnan University, Yunnan Provincial Science and Technology Department
Openalex Percentile: Top 68%
Vascular Tumors and Angiosarcomas
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever — Jian Zhao, Yixuan Dang · Frontiers in Oncology (2025) | TGRS Research Map | TGRS