Disruption of electrophysiological rhythms and memory impairment in an Alzheimer’s transgenic rat model
Our findings suggest that pathological synchronization between IEDs and HFOs in the hippocampus, along with neuropathological changes in both the hippocampus and entorhinal cortex, may contribute to memory dysfunction in AD, highlighting a potential mechanistic link between epileptiform activity, AD biomarker changes, and cognitive decline.
Authors
- Anatol Bragin (ORCID: https://orcid.org/0000-0003-1207-8481)
- Mychica Jones
- Udaya Kumar (ORCID: https://orcid.org/0000-0003-0725-0195)
- Keith Vossel
- Sally A. Frautschy (ORCID: https://orcid.org/0000-0003-0194-0363)
- Miaomiao Wang (ORCID: https://orcid.org/0000-0002-0852-8753)
- Lin Li (ORCID: https://orcid.org/0000-0002-9996-9377)
- Xiaoxiao Tao
- Cansheng Zhu
- Gregory M. Cole
- Jerome Engel
- Kapil Manglani
- Alexander Bombino
Institutions
- University of North Texas (US)
- University of California, Los Angeles (US)
- Neurobehavioral Systems (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13195-025-01841-4
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke