Optimizing management of uncomplicated acute malnutrition in children in rural Niger: a 3-arm individually randomized, controlled, noninferiority trial
Only the ComPAS protocol demonstrated noninferiority to standard treatment in ITT and PP analyses for children with MUAC <125 mm or edema. The OptiMA protocol's lower performance is unclear, but it suggests that reduced RUTF dosage had limited influence on overall child growth, as ComPAS used less RUTF than OptiMA. For the most malnourished children with MUAC <115 mm or edema, the standard protocol showed a higher recovery proportion, primarily due to better attendance rather than differences in mortality or growth at 6 mo. Further studies are needed to better understand the acceptability and population-level impact of simplified protocols in multiple settings.
Authors
- André Briend (ORCID: https://orcid.org/0000-0001-9390-8541)
- Harouna Boubacar
- Maguy Daurès (ORCID: https://orcid.org/0000-0003-2878-4524)
- Xavier Anglaret (ORCID: https://orcid.org/0000-0003-3319-8423)
- Benjamin Séri (ORCID: https://orcid.org/0000-0001-8989-7923)
- Valérie Journot (ORCID: https://orcid.org/0000-0003-1188-9565)
- Kevin P. Q. Phelan (ORCID: https://orcid.org/0000-0002-7017-7464)
- Jean-Claude Azani
- Baweye Mayoum
- Renaud Becquet (ORCID: https://orcid.org/0000-0003-3277-0985)
- Jérémie Hien
- Victoire Hubert
- Ahmad A. G. M. Aly
- Atté Sanoussi
- Mahamadou Aboubacar
- Cécile Cazes (ORCID: https://orcid.org/0000-0002-5501-6224)
- Suvi T. Kangas (ORCID: https://orcid.org/0000-0003-1477-7649)
- Susan Shepherd (ORCID: https://orcid.org/0000-0001-9515-4333)
- Jean Jacques Koffi (ORCID: https://orcid.org/0009-0005-8972-8114)
- Aurélie Beuscart
- Moumouni Kinda
Institutions
- Université de Bordeaux (FR)
- Inserm (FR)
- Alliance for International Medical Action (SN)
- Bordeaux Population Health (FR)
- United Nations Children's Fund Niger (NE)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Programme PAC-CI (CI)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.07.004
- Citations
- 3
- Primary Topic
- Child Nutrition and Water Access
- Type
- article
- Field-Weighted Citation Impact
- 3.36
Funders
- European Commission
- Institut National de la Santé et de la Recherche Médicale
- Université de Montpellier