The tryptophan–serotonin axis in albinism: an interesting lead?
Serotonin and other tryptophan-derived metabolites are altered in patients with albinism, with a distinct shift towards the serotonin pathway and impaired serotonin degradation. These metabolic disturbances suggest a potential link between tryptophan metabolism and pigmentation defects. Tryptophan profiling may offer novel diagnostic or therapeutic avenues for albinism.
Authors
- Benoı̂t Arveiler (ORCID: https://orcid.org/0000-0002-2987-2932)
- S. Matar
- Camille Huet
- Benoît Gendrot
- Guillemette Fouquet (ORCID: https://orcid.org/0000-0002-3751-393X)
- Marion Falabrègue (ORCID: https://orcid.org/0000-0001-7747-7294)
- Bénédicte Oulès (ORCID: https://orcid.org/0000-0001-8269-4306)
- Smail Hadj-Rabia (ORCID: https://orcid.org/0000-0001-6801-7106)
- Vincent Michaud (ORCID: https://orcid.org/0000-0002-5788-392X)
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Hôpital Cochin (FR)
- Laboratory of Excellence GR-Ex (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Sud Francilien (FR)
- Institut Cochin (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Maladies Rares: Génétique et Métabolisme (FR)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/bjd/ljaf333
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00