TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer
UA, a bioactive triterpenoid of HDW, inhibits CRC development by targeting and suppressing RPLP1 expression. These findings provide novel insights into the therapeutic of UA for CRC and highlight RPLP1 as a promising target for intervention.
Authors
- Limin Zhu (ORCID: https://orcid.org/0000-0002-8723-7427)
- XU Zhen-ye (ORCID: https://orcid.org/0000-0001-9449-4846)
- Haixia Shi
- Haibin Deng
Institutions
- Shanghai Ninth People's Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1007/s12672-025-03486-z
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Science and Technology Commission of Shanghai Municipality