Early thelarche, reproductive hormones, and MRI-based breast density: a prospective study in China
In this cohort study, earlier thelarche (even between 8.0 and 9.0 years) was associated with higher %FGV and FGV. Prolonged estrogen exposure may represent a modifiable mediator that could be targeted for breast cancer prevention strategies in girls with earlier puberty.
Authors
- Ying Sun (ORCID: https://orcid.org/0000-0002-1720-8540)
- Deyun Liu (ORCID: https://orcid.org/0000-0001-7319-3331)
- Yinghong Li (ORCID: https://orcid.org/0000-0003-3629-519X)
- Ya Wang (ORCID: https://orcid.org/0000-0001-6498-6022)
- Yue Yu (ORCID: https://orcid.org/0000-0002-3900-1217)
- Li‐Wei Zou (ORCID: https://orcid.org/0000-0003-1156-4162)
- Wenqing Liu (ORCID: https://orcid.org/0009-0008-9780-8706)
Institutions
- Anhui Medical University (CN)
- Anhui Provincial Children's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13058-025-02116-4
- Primary Topic
- Digital Radiography and Breast Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University