Early on-treatment LSM reliably predicts liver-related events in CHB patients with significant fibrosis and cirrhosis
On-treatment LSM measured 1-3 years after antiviral therapy offers superior predictive accuracy for LREs compared with baseline or LSM changes, with LSM <10 kPa indicating a significantly lower risk, likely due to improved lobular architecture.
Authors
- Tongtong Meng (ORCID: https://orcid.org/0009-0002-4746-3662)
- Yameng Sun (ORCID: https://orcid.org/0000-0003-2981-9936)
- Xinyan Zhao (ORCID: https://orcid.org/0000-0002-8016-4368)
- Mingyi Xu (ORCID: https://orcid.org/0000-0002-4834-3542)
- Yongpeng Chen (ORCID: https://orcid.org/0000-0002-9015-9861)
- Jidong Jia (ORCID: https://orcid.org/0000-0002-9407-8890)
- Jialing Zhou (ORCID: https://orcid.org/0000-0001-5075-6656)
- Wen Xie (ORCID: https://orcid.org/0000-0002-7314-8175)
- Hong You (ORCID: https://orcid.org/0000-0001-9409-1158)
- Shuyan Chen (ORCID: https://orcid.org/0000-0003-2400-8413)
- Hongxin Piao
- Mengyang Zhang (ORCID: https://orcid.org/0000-0003-4267-1761)
- Xiaoning Wu (ORCID: https://orcid.org/0000-0001-7002-4305)
- Huiguo Ding (ORCID: https://orcid.org/0000-0003-2153-5699)
- Xiaoyuan Xu (ORCID: https://orcid.org/0000-0001-7531-5881)
- Hui Ma (ORCID: https://orcid.org/0009-0000-7243-9707)
- Guofeng Chen
- Xiaoqian Xu (ORCID: https://orcid.org/0009-0009-8185-1053)
- Bingqiong Wang (ORCID: https://orcid.org/0009-0005-3439-6810)
- Xiaojuan Ou (ORCID: https://orcid.org/0009-0002-4662-4970)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-9027-4974)
- Anlin Ma
Institutions
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Fudan University (CN)
- China-Japan Friendship Hospital (CN)
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Nanfang Hospital (CN)
- Peking University People's Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai East Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Peking University First Hospital (CN)
- Yanbian University Hospital (CN)
- Beijing YouAn Hospital (CN)
- Beijing Friendship Hospital (CN)
- Beijing Ditan Hospital (CN)
- Sunyani Technical University (GH)
- Southern Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1097/hep.0000000000001504
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71