Clinical and hematological characteristics of beta-plus thalassemia and uncommon beta-chain hemoglobin variants in Northern Thailand
All <i>HBB</i> mutations causing β<sup>+</sup>-thalassemia in this study were promoter mutations. β<sup>+</sup>/β<sup>0</sup>-thalassemia results in transfusion-dependent thalassemia, whereas β<sup>+</sup>-thalassemia/Hb E disease is associated with mild disease. Beta-chain Hb variants when coinherited with β-thalassemia mostly result in mild or moderate phenotypes, and the clinical characteristics depend on the type of Hb variant.
Authors
- Kanda Fanhchaksai (ORCID: https://orcid.org/0000-0003-3790-4444)
- Supawadee Maneekesorn (ORCID: https://orcid.org/0009-0000-8200-8652)
- Pimlak Charoenkwan (ORCID: https://orcid.org/0000-0002-9123-9177)
- Lalita Sathitsamitphong (ORCID: https://orcid.org/0000-0003-4774-259X)
- Rungrote Natesirinilkul (ORCID: https://orcid.org/0000-0002-9840-3443)
- Adisak Tantiworawit (ORCID: https://orcid.org/0000-0002-2381-9292)
- Chane Choed-Amphai (ORCID: https://orcid.org/0000-0002-2520-1162)
- Punwadee Rukwong
Institutions
- Chiang Mai University (TH)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1080/07853890.2025.2551815
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00