<scp>IRANCANSURV</scp> : A comprehensive analysis of childhood cancer survival in Iran
We aimed to assess the 5-year survival probability of childhood cancer in Iran, utilizing data from eight population-based cancer registries across the country. The study employed data from 1809 childhood cancer patients aged 0-14 years, diagnosed between 2014 and 2016. Patients underwent active and passive follow-up procedures, and cases with uncertain vital status were excluded. We used the relative survival method to estimate age-standardized net survival probability for childhood cancer in Iran. The 5-year net survival for leukemia was 67.85% (95% confidence interval [CI] = 64.57, 70.90), while for central nervous system (CNS) cancers, it was 48.63% (95% CI = 43.21, 53.82). An analysis of regional disparities revealed a significant discrepancy of 14.56% in the 5-year survival of childhood leukemia, from 56.96 % in West Azerbaijan to 71.52% in Fars province. The geographical disparity in the 5-year survival of childhood CNS cancer became more pronounced, with a staggering 57.33% difference ranging from 73.50% in Khuzestan to 16.17% in Isfahan provinces. The study highlights low childhood cancer survival rates in Iran and calls for a robust surveillance system, public awareness campaigns, implementing national clinical practice guidelines, and financial support from government and NGOs to improve patient outcomes.
Authors
- Fereshte Lotfi (ORCID: https://orcid.org/0000-0002-3251-6226)
- Arash Golpazir (ORCID: https://orcid.org/0000-0003-2901-2243)
- Roya Dolatkhah (ORCID: https://orcid.org/0000-0002-6897-7120)
- Majid Yaghoobi‐Ashrafi
- Allison Domingues (ORCID: https://orcid.org/0000-0003-1804-6237)
- Habibollah Pirnejad (ORCID: https://orcid.org/0000-0001-9284-5702)
- Zahra Ravankhah (ORCID: https://orcid.org/0000-0003-3593-1158)
- Sepideh Abdi (ORCID: https://orcid.org/0000-0002-1907-9471)
- Azin Nahvijou (ORCID: https://orcid.org/0000-0003-1973-7638)
- Saeed Nemati (ORCID: https://orcid.org/0000-0002-6793-0398)
- Kazem Zendehdel (ORCID: https://orcid.org/0000-0002-0269-4945)
- Saba Alvand (ORCID: https://orcid.org/0000-0002-8149-2056)
- Maria Cheraghi
- Abbas Rezaeianzadeh
- Elham Mohebbi
- Azam Bazarafshan
- Elnaz Saeedi
- Nastaran Niami
Institutions
- Isfahan University of Medical Sciences (IR)
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Iran University of Medical Sciences (IR)
- Tabriz University of Medical Sciences (IR)
- Georgetown University (US)
- Shiraz University of Medical Sciences (IR)
- Kerman University of Medical Sciences (IR)
- Nuffield Orthopaedic Centre (GB)
- Urmia University (IR)
- University of Isfahan (IR)
- Kermanshah University of Medical Sciences (IR)
- Shariati Hospital (IR)
- Motamed Cancer Institute (IR)
- Centre international de recherche sur le cancer (FR)
- Urmia University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Mazandaran University of Medical Sciences (IR)
- University of Bologna (IT)
Publication Details
- Journal
- International Journal of Cancer
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/ijc.70100
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00