Behavioral characterization of triple-hit schizophrenia-like Lisket rats derived from the Long Evans strain through acute and chronic behavioral tests
This study provides the first comprehensive behavioral characterization of the Lisket model, a triple-hit schizophrenia-like rat strain derived from Long Evans rats, under both acute and chronic testing conditions. The automated, experimenter-free approach used in this study offers a promising tool for complex behavioral assessment. Furthermore, the findings emphasize the importance of individualized behavioral analysis alongside group-level assessments to enhance the translational validity of preclinical neuropsychiatric research.
Authors
- Gyöngyi Horváth (ORCID: https://orcid.org/0000-0002-6025-4577)
- Péter Liszli
- Gábor Braunitzer (ORCID: https://orcid.org/0000-0001-8983-5175)
- László G. Nyúl (ORCID: https://orcid.org/0000-0002-3826-543X)
- Gabriella Kékesi (ORCID: https://orcid.org/0000-0002-0185-2155)
- Leatitia Gabriella Adlan (ORCID: https://orcid.org/0000-0003-3260-2148)
- László Körmöczi (ORCID: https://orcid.org/0000-0002-3833-0609)
- Szonja B. Plesz
- Anna Zoldi
Institutions
- University of Szeged (HU)
- Sárospatak Reformed Theological University (HU)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fpsyt.2025.1601714
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Szegedi Tudományegyetem