In This Issue

Cancer doesn't just grow; it changes the environment around it to help it spread and resist treatment.To thrive, tumors reshape their surroundings, turning nearby healthy cells into accomplices.This surrounding network, known as the tumor microenvironment (TME), is a complex ecosystem made up of immune cells, blood vessels, and structural support cells.One important player in the TMEs is a group of support cells called cancer-associated fibroblasts (CAFs).These cells help build the structure around tumors, regulate immune responses, promote blood vessel growth, and support cancer cell survival.However, not all CAFs are the same-Some help tumors grow, while others might slow them down.