Shared and distinct alterations of thalamic subregional functional connectivity in early- and late-onset obsessive-compulsive disorder
These findings reveal both shared and distinct thalamic connectivity patterns in EO-OCD and LO-OCD patients. Sensory-motor networks exhibiting thalamic hyperconnectivity are critical for the manifestation of OCD, regardless of age of onset. The frontal-parietal network and thalamic hyperconnectivity may present a compensatory mechanism in EO-OCD patients, while hypoconnectivity with the frontoparietal network may reflect a neural mechanism underlying LO-OCD.
Authors
- Feng Gao (ORCID: https://orcid.org/0000-0002-3320-5702)
- Xiongzhao Zhu (ORCID: https://orcid.org/0000-0002-7573-0740)
- Jie Fan (ORCID: https://orcid.org/0000-0001-6058-5918)
- Zhiyan Wang (ORCID: https://orcid.org/0000-0001-7910-3245)
- Qianmei Yu
- Chuman Xiao (ORCID: https://orcid.org/0009-0001-9666-5001)
- Q Kong
- Xiang Wang (ORCID: https://orcid.org/0000-0001-9258-2017)
- Yao Liu (ORCID: https://orcid.org/0000-0003-1782-7322)
- Yan Han (ORCID: https://orcid.org/0000-0002-2881-1601)
- Qian Liu (ORCID: https://orcid.org/0000-0001-8307-9460)
Institutions
- Central South University (CN)
- National Institute of Mental Health (JP)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725100548
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China