Mechanisms of Propolis Ethanol Extracts to Alleviate Sarcopenia based on Network Pharmacology and Experimental Validation
This study identifies Ap as the key active compound in PEE that alleviates Sar by downregulating TNFα and IL6 and inhibiting the JAK-STAT pathway. The results provide a molecular basis for the use of propolis as a natural intervention for Sar and support its development as a functional food or therapeutic agent targeting age-related muscle degeneration.
Authors
- Conglin Jiang
- Tao Chen (ORCID: https://orcid.org/0000-0001-8811-4093)
- Congying Song
- Hongru Guo
- Songhao Tian (ORCID: https://orcid.org/0000-0002-9492-5826)
- Wei Feng (ORCID: https://orcid.org/0000-0001-5375-6045)
Institutions
- Shanxi Agricultural University (CN)
- Shanxi Medical University (CN)
- Shanxi Fenyang Hospital (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-08-28
- DOI
- https://doi.org/10.2174/0113862073397434250731053716
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00