Smart thin porous calcium phosphate coatings for local antibiotic delivery
We successfully embedded VAN into β-TCP coatings by preparing suspensions containing VAN-loaded supraparticles as feedstock for the HVSFS process. High-performance liquid chromatography analysis confirmed that VAN maintained its chemical integrity during spraying, with spectra comparable to untreated controls, indicating no thermal degradation. The resulting multifunctional coatings therefore combined the osteoconductive potential of β-TCP with the antibacterial activity of VAN. These findings demonstrate that HVSFS is a viable technique for producing bioactive coatings that simultaneously promote bone integration and enable local antibiotic delivery, offering a potential strategy to mitigate both aseptic loosening and infection risks in arthroplasty.
Authors
- Bianca Riedel
- Andreas Killinger (ORCID: https://orcid.org/0000-0002-0132-1098)
- Michael Seidenstuecker (ORCID: https://orcid.org/0000-0001-6643-6358)
- Sofia Dembski (ORCID: https://orcid.org/0000-0003-0427-1644)
- Long‐Quan R. V. Le (ORCID: https://orcid.org/0009-0009-2633-3579)
- Maria Carolina Lanzino (ORCID: https://orcid.org/0009-0006-2892-2404)
- Anika Höppel (ORCID: https://orcid.org/0009-0004-7968-3509)
- Mirjam Rech
Institutions
- University of Stuttgart (DE)
- University of Freiburg (DE)
- University of Würzburg (DE)
- University Medical Center Freiburg (DE)
- Stuttgart Technical University of Applied Sciences (DE)
- Fraunhofer Institute for Silicate Research (DE)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13104-025-07453-3
- Citations
- 1
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Deutsche Forschungsgemeinschaft
- Albert-Ludwigs-Universität Freiburg