Integrated fecal macrogenomic and metabolomic analyses reveal celiac disease flora and metabolic profiles associated with Chinese populations
Our study revealed specific alterations in the gut microbiome and metabolome of Chinese CeD patients through a multi-omics integration strategy. We found that CeD individuals carrying CeD risk genes may possess a unique intestinal flora composition, and this intestinal flora may, to some extent, explain the pathogenesis of CeD beyond the contributions of genes and gluten intake.
Authors
- Tian Shi (ORCID: https://orcid.org/0000-0002-7173-9502)
- Feng Gao (ORCID: https://orcid.org/0000-0002-3320-5702)
- Jinjin Xie (ORCID: https://orcid.org/0000-0002-2738-146X)
- Wenjie Kong
- Huan Liu (ORCID: https://orcid.org/0000-0003-3909-0931)
- Na Li (ORCID: https://orcid.org/0000-0001-6163-1648)
- Weidong Liu (ORCID: https://orcid.org/0000-0001-7954-7700)
- Shenglong Xue (ORCID: https://orcid.org/0009-0009-0650-8300)
- Shanxia Yao
Institutions
- Xinjiang Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s12967-025-06991-5
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang