Association of High-Sensitivity Cardiac Troponin I, Platelet Counts, and Total Bilirubin/Albumin Ratio with the Severity of Neonatal Hyperbilirubinemia

This study aimed to investigate the association between serum high-sensitivity cardiac troponin I (hs-cTnI) concentrations, platelet counts, and the severity of neonatal hyperbilirubinemia (NHB), as well as their correlation with the total bilirubin/albumin (B/A) ratio. A total of 82 neonates diagnosed with NHB and treated at JingMen People's Hospital of Hubei Province, China, between September 2023 and December 2023 were enrolled. Participants were categorized into mild and severe NHB groups based on total bilirubin levels. Serum hs-cTnI concentrations, platelet counts, and total bile acid levels were compared between groups. Correlations among hs-cTnI, platelet counts, and the B/A ratio were assessed. Neonates in the severe NHB group exhibited significantly higher hs-cTnI concentrations (median 64.1 [31.7, 92.1] ng/mL) compared with those in the mild NHB group (median 41.9 [17.55, 60.4] ng/mL; p=0.015). The B/A ratio was also significantly higher in the severe group (10.5 [10.0, 10.9] vs. 8.4 [7.9, 8.9]; p<0.001). No significant differences were observed between groups regarding platelet counts or total bile acid levels. Additionally, neither platelet count nor the B/A ratio demonstrated a significant correlation with hs-cTnI concentrations. Neonates with severe hyperbilirubinemia exhibited significantly elevated hs-cTnI concentrations and B/A ratios. However, hs-cTnI levels were not significantly influenced by platelet counts or the B/A ratio.