Identification of tear lipid biomarkers in women with dry eye disease and the impact of intense pulsed light therapy: a case-control study
Dry-eye subtypes appear to possess discrete lipidomic signatures; consequently, the lipid panel identified here could serve as a set of potential therapeutic targets. The dissociation between clinical improvement and lipidomic stability after IPL indicates that the therapy may benefit the ocular surface through mechanisms other than large-scale remodelling of the tear-film lipid layer, highlighting the need to explore complementary therapeutic pathways.
Authors
- Arantxa Acera (ORCID: https://orcid.org/0000-0002-6942-6144)
- Alejandro Blasco‐Martinez (ORCID: https://orcid.org/0000-0003-4652-1509)
- Silvia López-Plandolit
- Francisco D. Rodríguez (ORCID: https://orcid.org/0000-0002-8322-2711)
- Beatriz Abad‐García (ORCID: https://orcid.org/0000-0001-6945-5730)
- Oliver Ibarrondo (ORCID: https://orcid.org/0000-0003-3310-719X)
- Elena Vecino (ORCID: https://orcid.org/0000-0002-1672-5132)
- Noelia Ruzafa (ORCID: https://orcid.org/0000-0002-1853-0099)
- Xandra Pereiro (ORCID: https://orcid.org/0000-0003-2973-0405)
- María Alba Pérez Romero (ORCID: https://orcid.org/0000-0002-2522-8074)
- Antonio J. Mateo-Orobia
- Juan A. Durán (ORCID: https://orcid.org/0009-0009-3598-4330)
Institutions
- Ikerbasque (ES)
- Mondragon Unibertsitatea (ES)
- University of the Basque Country (ES)
- Universidad de Salamanca (ES)
- Hospital de Basurto (ES)
- Clinic IMQ Zorrotzaurre (ES)
- Hospital Universitario Miguel Servet (ES)
- Hospital Nuestra Señora de Alarcos (ES)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s12886-025-04315-1
- Citations
- 1
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Eusko Jaurlaritza
- Ministerio de Ciencia e Innovación