Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome
iCCA is characterised by a profoundly immunosuppressive TME that impairs B-cell function through soluble factors and cellular interactions. Our findings identify B cells as biomarkers and therapeutic targets, supporting strategies to restore B-cell function and promote mature TLS to enhance immunotherapy responsiveness in iCCA.
Authors
- Tiziana Pressiani (ORCID: https://orcid.org/0000-0001-6919-1536)
- Barbara Cassani (ORCID: https://orcid.org/0000-0002-4115-8109)
- Luca Di Tommaso (ORCID: https://orcid.org/0000-0002-9013-4728)
- Giulia Milardi (ORCID: https://orcid.org/0000-0002-5401-5377)
- Antonella Cammarota (ORCID: https://orcid.org/0000-0001-9967-4694)
- Ines Malenica (ORCID: https://orcid.org/0000-0002-5401-4024)
- Ilaria Montali (ORCID: https://orcid.org/0000-0002-0565-704X)
- Enrico Lugli (ORCID: https://orcid.org/0000-0002-1964-7678)
- Salvatore Piscuoglio (ORCID: https://orcid.org/0000-0003-2686-2939)
- Ana Lleò (ORCID: https://orcid.org/0000-0002-0561-7902)
- Paolo Uva (ORCID: https://orcid.org/0000-0002-9524-8492)
- Michela Anna Polidoro (ORCID: https://orcid.org/0000-0002-9162-6855)
- Luca Lambroia (ORCID: https://orcid.org/0000-0002-8724-1485)
- Chiara Camisaschi (ORCID: https://orcid.org/0000-0002-5205-919X)
- Alessio Aghemo (ORCID: https://orcid.org/0000-0003-0941-3226)
- Chiara Raggi (ORCID: https://orcid.org/0000-0003-2473-3535)
- Barbara Franceschini (ORCID: https://orcid.org/0000-0001-6348-248X)
- Roberta Carriero (ORCID: https://orcid.org/0000-0001-8619-6152)
- Guido Costa (ORCID: https://orcid.org/0000-0003-3986-8790)
- Cristiana Soldani (ORCID: https://orcid.org/0000-0001-5041-9588)
- Paolo Kunderfranco (ORCID: https://orcid.org/0000-0001-7477-8710)
- Marco Erreni (ORCID: https://orcid.org/0000-0002-1922-0818)
- Davide Cangelosi (ORCID: https://orcid.org/0000-0002-6010-5619)
- Simone Puccio (ORCID: https://orcid.org/0000-0003-4007-4365)
- Rita Balsano
- Giulio Lodetti-Zangrandi
- Guido Torzilli
- Lorenza Rimassa
Institutions
- Humanitas University (IT)
- University of Milan (IT)
- Istituto Giannina Gaslini (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Florence (IT)
Publication Details
- Journal
- Gut
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1136/gutjnl-2025-334861
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Associazione Italiana per la Ricerca sul Cancro