CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation
CircRERE exacerbated myocardial I/R injury by promoting UHRF1 mRNA degradation and mitochondrial dysfunction. Targeting the circRERE/UHRF1/Drp1 axis may represent a novel therapeutic strategy against myocardial I/R injury.
Authors
- Wang Wang (ORCID: https://orcid.org/0009-0001-0217-2186)
- Shihui Fu (ORCID: https://orcid.org/0000-0001-6707-9049)
- Ping Ping (ORCID: https://orcid.org/0000-0002-5767-5899)
- Qiong Liu (ORCID: https://orcid.org/0000-0001-9344-4193)
- Yan Nie
- Yali Zhao (ORCID: https://orcid.org/0000-0003-0052-6486)
- Zhitao Gao
- Zhirui Li (ORCID: https://orcid.org/0000-0003-0804-166X)
Institutions
- Capital Medical University (CN)
- General Administration of Quality Supervision, Inspection and Quarantine (CN)
- Hainan 301 Hospital (CN)
- Chinese People's Liberation Army (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1097/cm9.0000000000003757
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81