Reduced Brain Iron and Striatal Hyperdopaminergia in Schizophrenia: A Quantitative Susceptibility Mapping MRI and PET Study
These findings suggest that lower levels of non-neuromelanin-bound iron in the SN-VTA contribute to striatal hyperdopaminergia in schizophrenia. Further investigation is warranted to understand the role of low iron in schizophrenia and its potential as a treatment target.
Authors
- Oliver Howes (ORCID: https://orcid.org/0000-0002-2928-1972)
- Leigh Townsend (ORCID: https://orcid.org/0000-0002-2037-7847)
- Stephen J. Kaar (ORCID: https://orcid.org/0000-0003-0194-0806)
- Mattia Veronese (ORCID: https://orcid.org/0000-0003-3562-0683)
- Ben K. Statton (ORCID: https://orcid.org/0000-0001-5118-7977)
- Giovanna Nordio (ORCID: https://orcid.org/0000-0002-7835-2992)
- Ian Everall (ORCID: https://orcid.org/0000-0003-3957-3861)
- Jan Sedlacik (ORCID: https://orcid.org/0000-0003-3125-1083)
- Alaine Berry (ORCID: https://orcid.org/0000-0001-6049-4418)
- Seth C. Hopkins (ORCID: https://orcid.org/0000-0003-3999-2281)
- Luke James Vano (ORCID: https://orcid.org/0000-0003-1624-490X)
- Grazia Rutigliano (ORCID: https://orcid.org/0000-0001-6014-5357)
- Robert Ali McCutcheon (ORCID: https://orcid.org/0000-0003-1102-2566)
- Kenneth S. Koblan (ORCID: https://orcid.org/0000-0001-6103-2629)
- Amir Fazlollahi (ORCID: https://orcid.org/0000-0001-5886-0511)
- Valeria Finelli (ORCID: https://orcid.org/0009-0006-1026-4626)
Institutions
- The Royal Melbourne Hospital (AU)
- University of Padua (IT)
- The University of Queensland (AU)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Hammersmith Hospital (GB)
- Oxford Health NHS Foundation Trust (GB)
- Warneford Hospital (GB)
- University of Manchester (GB)
- University of Oxford (GB)
- Sumitomo Dainippon Pharma (United States) (US)
- Imperial College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1176/appi.ajp.20240512
- Citations
- 6
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34